ParkinsonCanadaV1, Main, Exploration, bibRecord, 001918

Rotenone, Paraquat, and Parkinson's Disease

Identifieur interne : 001918 ( Main/Exploration ); précédent : 001917; suivant : 001919

Rotenone, Paraquat, and Parkinson's Disease

Auteurs : Caroline M. Tanner [États-Unis] ; Freya Kamel [États-Unis] ; G. Webster Ross [États-Unis] ; Jane A. Hoppin [États-Unis] ; Samuel M. Goldman [États-Unis] ; Monica Korell [États-Unis] ; Connie Marras [Canada] ; Grace S. Bhudhikanok [États-Unis] ; Meike Kasten [Allemagne] ; Anabel R. Chade [Argentine] ; Kathleen Comyns [États-Unis] ; Marie Barber Richards [États-Unis] ; Cheryl Meng [États-Unis] ; Benjamin Priestley [États-Unis] ; Hubert H. Fernandez [États-Unis] ; Franca Cambi [États-Unis] ; David M. Umbach [États-Unis] ; Aaron Blair [États-Unis] ; Dale P. Sandler [États-Unis] ; J. William Langston [États-Unis]

Source :

Environmental health perspectives [ 0091-6765 ] ; 2011.

RBID : Pascal:11-0374477

Descripteurs français

Pascal (Inist)
- Paraquat, Vieillissement, Sénescence, Agriculture, Epidémiologie, Santé publique, Environnement, Maladie de Parkinson, Fongicide, Herbicide, Insecticide, Polluant organique persistant, Santé et environnement.
Wicri :
- topic : Santé publique, Herbicide, Insecticide.

English descriptors

KwdEn :
- Ageing, Agriculture, Environment, Epidemiology, Fungicide, Health and environment, Herbicide, Insecticide, Paraquat, Parkinson disease, Persistent organic pollutant, Public health, Senescence.

Abstract

BACKGROUND: Mitochondrial dysfunction and oxidative stress are pathophysiologic mechanisms implicated in experimental models and genetic forms of Parkinson's disease (PD). Certain pesticides may affect these mechanisms, but no pesticide has been definitively associated with PD in humans. OBJECTIVES: Our goal was to determine whether pesticides that cause mitochondrial dysfunction or oxidative stress are associated with PD or clinical features of parkinsonism in humans. METHODS: We assessed lifetime use of pesticides selected by mechanism in a case-control study nested in the Agricultural Health Study (AHS). PD was diagnosed by movement disorders specialists. Controls were a stratified random sample of all AHS participants frequency-matched to cases by age, sex, and state at approximately three controls:one case. RESULTS: In 110 PD cases and 358 controls, PD was associated with use of a group of pesticides that inhibit mitochondrial complex I [odds ratio (OR) = 1.7; 95% confidence interval (CI), 1.0-2.8] including rotenone (OR = 2.5; 95% CI, 1.3-4.7) and with use of a group of pesticides that cause oxidative stress (OR = 2.0; 95% CI, 1.2-3.6), including paraquat (OR = 2.5; 95% CI, 1.4-4.7). CONCLUSIONS: PD was positively associated with two groups of pesticides defined by mechanisms implicated experimentally-those that impair mitochondrial function and those that increase oxidative stress-supporting a role for these mechanisms in PD pathophysiology.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114824

Affiliations:

Allemagne, Argentine, Canada, États-Unis
Californie, Caroline du Nord, Hawaï, Kentucky, Maryland, Ohio, Ontario
Toronto
Université de Toronto

Le document en format XML

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<author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Toronto Western Hospital, University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Bhudhikanok, Grace S" sort="Bhudhikanok, Grace S" uniqKey="Bhudhikanok G" first="Grace S." last="Bhudhikanok">Grace S. Bhudhikanok</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, California</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kasten, Meike" sort="Kasten, Meike" uniqKey="Kasten M" first="Meike" last="Kasten">Meike Kasten</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Departments of Neurology and Clinical and Molecular Neurogenetics, University of Lubeck</s1>
<s2>Lubeck</s2>
<s3>DEU</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Lubeck</wicri:noRegion>
<wicri:noRegion>University of Lubeck</wicri:noRegion>
<wicri:noRegion>Lubeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chade, Anabel R" sort="Chade, Anabel R" uniqKey="Chade A" first="Anabel R." last="Chade">Anabel R. Chade</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Institute of Cognitive Neurology, Institute of Neuroscience, Favaloro University</s1>
<s2>Buenos Aires</s2>
<s3>ARG</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Argentine</country>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Comyns, Kathleen" sort="Comyns, Kathleen" uniqKey="Comyns K" first="Kathleen" last="Comyns">Kathleen Comyns</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, California</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Barber Richards, Marie" sort="Barber Richards, Marie" uniqKey="Barber Richards M" first="Marie" last="Barber Richards">Marie Barber Richards</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services</s1>
<s2>Research Triangle Park, North Carolina</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Westat Inc.</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meng, Cheryl" sort="Meng, Cheryl" uniqKey="Meng C" first="Cheryl" last="Meng">Cheryl Meng</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, California</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Priestley, Benjamin" sort="Priestley, Benjamin" uniqKey="Priestley B" first="Benjamin" last="Priestley">Benjamin Priestley</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, California</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H." last="Fernandez">Hubert H. Fernandez</name>
<affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Center for Neurological Restoration, Cleveland Clinic</s1>
<s2>Cleveland, Ohio</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name>
<affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Department of Neurology, University of Kentucky</s1>
<s2>Lexington, Kentucky</s2>
<s3>USA</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Kentucky</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Umbach, David M" sort="Umbach, David M" uniqKey="Umbach D" first="David M." last="Umbach">David M. Umbach</name>
<affiliation wicri:level="2"><inist:fA14 i1="10"><s1>Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services</s1>
<s2>Research Triangle Park, North Carolina</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blair, Aaron" sort="Blair, Aaron" uniqKey="Blair A" first="Aaron" last="Blair">Aaron Blair</name>
<affiliation wicri:level="2"><inist:fA14 i1="11"><s1>Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services</s1>
<s2>Bethesda, Maryland</s2>
<s3>USA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sandler, Dale P" sort="Sandler, Dale P" uniqKey="Sandler D" first="Dale P." last="Sandler">Dale P. Sandler</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services</s1>
<s2>Research Triangle Park, North Carolina</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Langston, J William" sort="Langston, J William" uniqKey="Langston J" first="J. William" last="Langston">J. William Langston</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>The Parkinson's Institute</s1>
<s2>Sunnyvale, California</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Environmental health perspectives</title>
<title level="j" type="abbreviated">Environ. health perspect.</title>
<idno type="ISSN">0091-6765</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Environmental health perspectives</title>
<title level="j" type="abbreviated">Environ. health perspect.</title>
<idno type="ISSN">0091-6765</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Ageing</term>
<term>Agriculture</term>
<term>Environment</term>
<term>Epidemiology</term>
<term>Fungicide</term>
<term>Health and environment</term>
<term>Herbicide</term>
<term>Insecticide</term>
<term>Paraquat</term>
<term>Parkinson disease</term>
<term>Persistent organic pollutant</term>
<term>Public health</term>
<term>Senescence</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Paraquat</term>
<term>Vieillissement</term>
<term>Sénescence</term>
<term>Agriculture</term>
<term>Epidémiologie</term>
<term>Santé publique</term>
<term>Environnement</term>
<term>Maladie de Parkinson</term>
<term>Fongicide</term>
<term>Herbicide</term>
<term>Insecticide</term>
<term>Polluant organique persistant</term>
<term>Santé et environnement</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Santé publique</term>
<term>Herbicide</term>
<term>Insecticide</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">BACKGROUND: Mitochondrial dysfunction and oxidative stress are pathophysiologic mechanisms implicated in experimental models and genetic forms of Parkinson's disease (PD). Certain pesticides may affect these mechanisms, but no pesticide has been definitively associated with PD in humans. OBJECTIVES: Our goal was to determine whether pesticides that cause mitochondrial dysfunction or oxidative stress are associated with PD or clinical features of parkinsonism in humans. METHODS: We assessed lifetime use of pesticides selected by mechanism in a case-control study nested in the Agricultural Health Study (AHS). PD was diagnosed by movement disorders specialists. Controls were a stratified random sample of all AHS participants frequency-matched to cases by age, sex, and state at approximately three controls:one case. RESULTS: In 110 PD cases and 358 controls, PD was associated with use of a group of pesticides that inhibit mitochondrial complex I [odds ratio (OR) = 1.7; 95% confidence interval (CI), 1.0-2.8] including rotenone (OR = 2.5; 95% CI, 1.3-4.7) and with use of a group of pesticides that cause oxidative stress (OR = 2.0; 95% CI, 1.2-3.6), including paraquat (OR = 2.5; 95% CI, 1.4-4.7). CONCLUSIONS: PD was positively associated with two groups of pesticides defined by mechanisms implicated experimentally-those that impair mitochondrial function and those that increase oxidative stress-supporting a role for these mechanisms in PD pathophysiology.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Argentine</li>
<li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Caroline du Nord</li>
<li>Hawaï</li>
<li>Kentucky</li>
<li>Maryland</li>
<li>Ohio</li>
<li>Ontario</li>
</region>
<settlement><li>Toronto</li>
</settlement>
<orgName><li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Californie"><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name>
</region>
<name sortKey="Barber Richards, Marie" sort="Barber Richards, Marie" uniqKey="Barber Richards M" first="Marie" last="Barber Richards">Marie Barber Richards</name>
<name sortKey="Barber Richards, Marie" sort="Barber Richards, Marie" uniqKey="Barber Richards M" first="Marie" last="Barber Richards">Marie Barber Richards</name>
<name sortKey="Bhudhikanok, Grace S" sort="Bhudhikanok, Grace S" uniqKey="Bhudhikanok G" first="Grace S." last="Bhudhikanok">Grace S. Bhudhikanok</name>
<name sortKey="Blair, Aaron" sort="Blair, Aaron" uniqKey="Blair A" first="Aaron" last="Blair">Aaron Blair</name>
<name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name>
<name sortKey="Comyns, Kathleen" sort="Comyns, Kathleen" uniqKey="Comyns K" first="Kathleen" last="Comyns">Kathleen Comyns</name>
<name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H." last="Fernandez">Hubert H. Fernandez</name>
<name sortKey="Goldman, Samuel M" sort="Goldman, Samuel M" uniqKey="Goldman S" first="Samuel M." last="Goldman">Samuel M. Goldman</name>
<name sortKey="Hoppin, Jane A" sort="Hoppin, Jane A" uniqKey="Hoppin J" first="Jane A." last="Hoppin">Jane A. Hoppin</name>
<name sortKey="Kamel, Freya" sort="Kamel, Freya" uniqKey="Kamel F" first="Freya" last="Kamel">Freya Kamel</name>
<name sortKey="Korell, Monica" sort="Korell, Monica" uniqKey="Korell M" first="Monica" last="Korell">Monica Korell</name>
<name sortKey="Langston, J William" sort="Langston, J William" uniqKey="Langston J" first="J. William" last="Langston">J. William Langston</name>
<name sortKey="Meng, Cheryl" sort="Meng, Cheryl" uniqKey="Meng C" first="Cheryl" last="Meng">Cheryl Meng</name>
<name sortKey="Priestley, Benjamin" sort="Priestley, Benjamin" uniqKey="Priestley B" first="Benjamin" last="Priestley">Benjamin Priestley</name>
<name sortKey="Sandler, Dale P" sort="Sandler, Dale P" uniqKey="Sandler D" first="Dale P." last="Sandler">Dale P. Sandler</name>
<name sortKey="Umbach, David M" sort="Umbach, David M" uniqKey="Umbach D" first="David M." last="Umbach">David M. Umbach</name>
<name sortKey="Webster Ross, G" sort="Webster Ross, G" uniqKey="Webster Ross G" first="G." last="Webster Ross">G. Webster Ross</name>
</country>
<country name="Canada"><region name="Ontario"><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name>
</region>
</country>
<country name="Allemagne"><noRegion><name sortKey="Kasten, Meike" sort="Kasten, Meike" uniqKey="Kasten M" first="Meike" last="Kasten">Meike Kasten</name>
</noRegion>
</country>
<country name="Argentine"><noRegion><name sortKey="Chade, Anabel R" sort="Chade, Anabel R" uniqKey="Chade A" first="Anabel R." last="Chade">Anabel R. Chade</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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La maladie de Parkinson au Canada (serveur d'exploration)

Rotenone, Paraquat, and Parkinson's Disease

Rotenone, Paraquat, and Parkinson's Disease

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	La maladie de Parkinson au Canada (serveur d'exploration)
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